Drug interactions are a concern associated with Kratom, a plant used for pain relief and other ailments. Read along to find out what you need to be cautious of.

What is Kratom?

Kratom is a plant native to Southeast Asia. It is also known as Mitragyna speciosa. It is being seen as a potential therapeutic agent, therefore, the increased international attention. Traditionally, kratom was widely used for medicinal purposes. Its leaves were used to relieve pain, treat sexual dysfunctions, among other uses.

Kratom is sold as leaves, capsule, pellet, gum, powder, or extract. It can be chewed, smoked, or consumed as a tea.

Kratom sell and use, however, banned in some countries. They include Australia, Malaysia, and Myanmar. Kratom is being used for self-management of pain or withdrawal symptoms in the united states of America. It is also used in relieving pain.

The kratom use is recommended in those living in regions where the distribution, possession, and use of the substance is legal.

kratom plants


  • Mitragynine

It is the most abundant active alkaloid. It is involved in the improvement of mood and has analgesic effects. It also promotes relaxation and stimulation. It acts on mu-opioid receptors.


  • 7-hydroxymitragynine

7-hydroxymitragynine is a terpenoid indole alkaloid extracted from Mitragyna speciosa. On the mu receptors, 7-hydroxymitragynine acts as an agonist.


Kratom’s Strains

Depending on the region where the plant is grown, different strains of kratom exist. Kratom is sold in three color varieties: Red, Green, and White. Regional kratom varieties exist within these colors. The various types are Malaysian, Thai, and Indo. You do want to be cautious of certain drug interactions with Kratom– since combining this herb with depressants can be a bad idea(or other sedatives).

Red Vein Kratom

It is the popular kratom strain. It is mainly used to relieve pain. The strain is easier to grow thus more abundant variety. The alkaloid concentration in the variety is very high as compared to other kratom’s varieties. Red Thai, Red Vein Sumatra, and Borneo Red are the regional strains falling within the Red Vein kratom’s varieties. Its low doses are recommended for boosting mood while higher doses are for sedation in the treatment of pain.

White Vein Kratom

The strain is recommended for stimulation effects and mood-boosting. It is advisable that one should take it during the day as it interferes with sleep. Pontianak White Horn, White Vein Sumatra, and Borneo White are the regional varieties within the White Vein Kratom.

Green Vein Kratom

The strain boosts energy and also has analgesic effects. It produces euphoria, therefore, commonly used for recreation. Green vein variety is added to White and Red kratoms to balance their potencies. The Malaysian Green and Pontianak Green Horn are the regional varieties within Green Vein Kratom.

kratom strains

Other Kratom Varieties

Yellow or Gold kratom

Purple kratom


Regional varieties including Bali, Indo, Maeng Da kratom, Riau, Vietnam and many others.


The Grades of Kratom

Kratom grading is done based on the potencies of the various brands. Processing methodology and the concentration of the alkaloid are the factors that determine this potency.

The following are the various grades in order of strongest to weakest: –

  • Ultra-Enhanced Grade (strongest)
  • Enhanced Grade
  • Super Grade
  • Premium Grade
  • Commercial Grade (weakest)

Make sure you stay aware of the potential drug interactions that are associated to Kratom.